FORMULATION AND EVALUATION OF PINACIDIL MONOHYDRATE TRANSDERMAL PATCHES

PAVANKUMAR KROSURI*; MAHESWARA REDDY DAGADA; GEETHAVANI GURRAPPAGARI; GEETHA DAKKA; PAVANI BURRAREDDY; BABU BONALA; MADHUSUDANA CHETTY CHALLA.

Abstract

JOURNAL OF COMPREHENSIVE PHARMACY - Vol 5, Issue 2, 2018

Pages: 35-40

FORMULATION AND EVALUATION OF PINACIDIL MONOHYDRATE TRANSDERMAL PATCHES

PAVANKUMAR KROSURI*, MAHESWARA REDDY DAGADA, GEETHAVANI GURRAPPAGARI, GEETHA DAKKA, PAVANI BURRAREDDY, BABU BONALA, MADHUSUDANA CHETTY CHALLA.

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Abstract:

Aim & Objective: The present research work is an attempt to formulate and evaluate matrix type transdermal patches of pinacidil monohydrate in order to improve patient compliance by sustaining its action and by avoiding its gastrointestinal side effects.

Methods: Transdermal patches of pinacidil monohydrate were developed with different ratios of hydrophobic polymers like Eudragit RS 100 and Ethyl cellulose T 50 (EC) polymer combinations by solvent evaporation technique. The Fourier transform infrared (FTIR) spectroscopy was used to confirm compatibility and to rule out any possible interactions between drug and polymers. Seven transdermal patch formulations (F1, F2, F3, F4, F5, F6 and F7) consisting Eudragit RS 100 and Ethyl cellulose T 50 in the ratios of 1:1,4:1,1:4,3:2&2:3 respectively were prepared. All formulations carried 4 % w/v of Tween 80 as penetration enhancer and 10 % w/v of Dibutyl phthalate as plasticizer in dichloromethane and methanol (4:1) solvent system. Data of in vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. From the kinetic studies it was found that the drug release showed zero order kinetics indicating that the drug release does not depends upon its concentration .Combination of polymers Eudragit RS 100 and Ethyl cellulose T 50 (2:3) showed better release for sufficiently long time.

Conclusion: The developed transdermal films prolonged release for 24 hrs and thus found useful to improve the patient compliance of Pinacidil monohydrate.

Keywords: Ethyl cellulose T50, Eudragit RS 100, in-vitro, Solvent evaporation technique, Transdermal patch.

References:<ol> <li style="text-align:justify">Chein YW. Novel Drug Delivery Systems. 2nd ed. New York: Marcel Dekker;1992. p. 1-2, 301-50.</li> <li style="text-align:justify">Tyle P. Drug Delivery Devices. Fundamentals and Applicat ions. New York: Marcel Dekker; 1998. p. 385-417.</li> <li style="text-align:justify">Desai BG, Annamalai AR, Divya B, Dinesh BM. Effect of enhancers on permeation kinetics of captopril for transdermal system. Asian J Pharm 2008;2:35-7.</li> <li style="text-align:justify">Langer R. Transdermal drug delivery: past progress, current status and future prospects. Adv Drug Del Rev 2004;56(5):557-8.</li> <li style="text-align:justify">Singh S, Singh J. Transdermal drug delivery by passive diffusion andiontophoresis: a review. Med Res Rev 1993;13:569-621.</li> <li style="text-align:justify">Ritschel WA, Hussain AS. The principles of permeation of substances across the skin. Methods Find Exp Clin Pharmacol 1998;10(1):39-56.</li> <li style="text-align:justify">Aqil M, Sultana Y, Ali A. Matrix type transdermal drug delivery systems of metoprolol tartrate: In vitro characterization. Act a Pharm 2003;53:119-25.</li> <li style="text-align:justify">Vyas SP, Khar RK. Controlled drug delivery concepts and advances. 1st ed. New Delhi: VallabhPrakashan; 2002. p. 411-47.</li> <li style="text-align:justify">9.Murthy SN, Hiremath. Transdermal Drug Delivery systems. In: Hiremath SRR, editor. Text book of industrial pharmacy. India: Orient longman private limited; 2008. p. 27-49.</li> <li style="text-align:justify">Sanap GS, Dama GY, Hande AS, Karpe SP, Nalawade SV, Kakade RS, et al. Preparation of transdermal monolithic systems of indapamide by solvent casting method and the use of vegetable oils as permeation enhancer. Int J Green Pharm 2008;2:129-33.</li> <li style="text-align:justify">Murthy TEGK, Kishore VS. Effect of casting solvent on permeability of antihypertensive drugs through ethyl cellulose films. J Sci Ind Res 2008; 67:147-50.</li> <li style="text-align:justify">Patel HJ, Patel JS, Desai BG, Patel KD. Design and evaluation of amlodipine besilate transdermal patches containing film former. Int J Pharma Res Dev 2009;7:1-12.</li> <li style="text-align:justify">Kulkarni RV, Mutalik S, Hiremath D. Effect of plasticizers on the permeability and mechanical properties of eudragit films for transdermal application. Indian J Pharm Sci 2002;64(1):28-31.</li> <li style="text-align:justify">Panigrahi L, Ghosal SK. Formulation and evaluation of pseudolatex transdermal drug delivery system of terbutaline sulphate. Indian J Pharm Sci 2002;64:79-82.</li> <li style="text-align:justify">Murthy TEGK and Kishore VS. Effect of casting solvent and polymer on permeability of propranolol hydrochloride through membrane controlled transdermal drug delivery system. Indian J Pharm Sci 2007;69(5):646-50.</li> <li style="text-align:justify">Subramanian K, Sathyapriya LS, Jayaprakash S, Prabhu RS, Abirami A, Madhumitha B et al. An Approach to the formulation and evaluation of transdermal DDS of isoxsuprine HCl. Int J Pharm Sci Tech 2008;1(1):22-8.</li> <li style="text-align:justify">Sankar V, Johnson DB, Sivanand V, Ravichandran V, Raghuraman, S, Velrajan G et al. Design and evaluation of nifedipine transdermal patches. Indian J Pharm Sci 2003;65(5):510-5.</li> <li style="text-align:justify">Shinde AJ, Garala KC, More HN. Development and characterization of transdermal therapeutics system of tramadol hydrochloride. Asian J Pharm 2008;2:265-9.</li> <li style="text-align:justify">Devi KV, Saisivam S, Maria GR, Deepti PU. Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug Dev Ind Pharm 2003;29(5):495-503.</li> <li style="text-align:justify">Pandit V, Khanum A, Bhaskaran S, Banu V. Formulation and evaluation of transdermal films for the treatment of overactive bladder. Int J Pharm Tech Res 2009;1(3):799-804.</li> <li style="text-align:justify">Rao V, Mamatha T, Mukkanti K and Ramesh. Transdermal drug delivery system for atomoxetine hydrochloride-in vitro and ex vivo evaluation. Current Trends in Biotechnology and Pharmacy 2009;3(2):188-96.</li> <li style="text-align:justify">Satturwar PM, Fulzele SV, Dorle AK. Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system:AAPS PharmSciTech. 2005;6(4):E649-54.</li> <li style="text-align:justify">http://en.wikipedia.org/wiki/Draiz_test access on 29-08-2010.</li> </ol>

International Journal of Advances in Microwave Technology

Abstract

FORMULATION AND EVALUATION OF PINACIDIL MONOHYDRATE TRANSDERMAL PATCHES

PAVANKUMAR KROSURI*, MAHESWARA REDDY DAGADA, GEETHAVANI GURRAPPAGARI, GEETHA DAKKA, PAVANI BURRAREDDY, BABU BONALA, MADHUSUDANA CHETTY CHALLA.