REVIEW ON THERAPEUTIC ADVANCEMENTS OF ALOPECIA AREATA (AA)

SURESH YADAV K*; VENKATESWARA REDDY B; SHAJAHA SK; RAVI B; SUDHAKAR M; MOULASAB P; MAHESH BABU

Abstract

JOURNAL OF COMPREHENSIVE PHARMACY - Vol 5, Issue 2, 2018

Pages: 49-57

REVIEW ON THERAPEUTIC ADVANCEMENTS OF ALOPECIA AREATA (AA)

SURESH YADAV K*, VENKATESWARA REDDY B, SHAJAHA SK, RAVI B, SUDHAKAR M, MOULASAB P, MAHESH BABU

Category:

Download PDF

Abstract:

Alopecia areata is a common condition characterized by sudden onset of patchy hair loss without signs of skin inflammation or scarring. It usually causes small, coin-sized, round patches of baldness on the scalp, although hair elsewhere such as the beard, eyebrows, eyelashes, body and limbs can be affected. In some people larger areas are affected and occasionally it can involve the whole scalp or even the entire body and scalp. Emotional strains, stresses and nervous disorders Aging, Infections, Hormonal imbalances generally causes of alopecia. Genetic predisposition, autoimmunity, and environmental factors play a major role in the etiopathogenesis of AA. Now days to re-growth the hair and lack of a uniform response to various therapies has made clinical trials in alopecia areata difficult to plan and implement. The present review describes that etiology, diagnosis and therapeutic management of alopecia areata. Treatment of alopecia areata is dependent on age of patient as well as the extent and duration of scalp involvement. Treatments include steroids, topical immunotherapy, topical minoxidil, anthralin, and immunosuppressants.

Keywords: Alopecia Areata, Hair loss, Skin, Baldness, Treatment.

References:<ol> <li style="text-align:justify">Safavi KH, Muller SA, Suman VJ, Moshell AN. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc. 1995;70:628-33. </li> <li style="text-align:justify">Tan E, Tay YK, Goh CL, Chin Giam Y. The pattern of alopecia areata in Singapore - A study of 219 Asians. Int J Dermatol. 2002;41:748-53. </li> <li style="text-align:justify">Wasserman D, Guzman-Sanchez DA, Scott K, McMichael A. Alopecia areata. Int J Dermatol. 2007;46:121-31.</li> <li style="text-align:justify">Price V. Alopecia areata: clinical aspects. J Invest Dermatol. 1991; 96: 685. </li> <li style="text-align:justify">Camacho F. Alopecia areata: clinical features. Dermatopathology. In: Camacho F, Montagna W, editors. Trichology: diseases of the pilosebaceus follicle. Madrid: Aula Medica Group; 1997. p.417-40.</li> <li style="text-align:justify">Shapiro J, Modani S. Alopecia areata: diagnosis and management. Int J Dermatol. 1999; 38:19-24. </li> <li style="text-align:justify">Tosti A, Fanti PA, Morelli R, Bardazzi F. Trachyonichia associated with alopecia areata: a clinical and pathological study. J Am Acad Dermatol. 1991; 25:266-70.</li> <li style="text-align:justify">MacDonald Hull SP, Wood ML, Hutchinson PE, Sladden M, Messenger AG. Guidelines for the management of alopecia areata. Br J Dermatol 2003;149:692-9. </li> <li style="text-align:justify">Delamere FM, Sladden MM, Dobbins HM, Leonardi-Bee J. Interventions for alopecia areata. Cochrane Database Syst Rev. 2008;2:CD004413.</li> <li style="text-align:justify">Agarwal A, Nath J, Barua KN. Twice weekly 5 mg betamethasone oral pulse therapy in the treatment of alopecia areata. J Eur Acad Dermatol Venereol 2006;20:1375-6. </li> <li style="text-align:justify">Luggen P, Hunziker T. High-dose intravenous corticosteroid pulse therapy in alopecia areata: own experience compared with the literature. J Dtsch Dermatol Ges 2008;6:375-8.</li> <li style="text-align:justify">Trueb RM. Systematic approach to hair loss in women. J Dtsch Dermatol Ges. 2010;8(4):284-298. </li> <li style="text-align:justify">Kos L, Conlon J. An update on alopecia areata. Curr Opin Pediatr. 2009;21(4):475-480.</li> <li style="text-align:justify">Blaumeiser B, van der Goot I, Fimmers R, et al. Familial aggregation of alopecia areata. J Am Acad Dermatol. 2006;54(4):627-632.</li> <li style="text-align:justify">Kyriakis KP, Paltatzidou K, Kosma E, Sofouri E, Tadros A, Rachioti E. Alopecia areata prevalence by gender and age. J Eur Acad Dermatol Venereol. 2009;23(5):572-573.</li> <li style="text-align:justify">Du Vivier A, Munro DD. Alopecia areata, autoimmunity and Down's syndrome. Br Med J. 1975; 1:191-4.</li> <li style="text-align:justify">Colombe BW, Price VH, Khoury EL. HLA class II antigen associations help to define two types of alopecia areata. J Am Acad Dermatol. 1995; 33:757-64.</li> <li style="text-align:justify">Muller SA, Winkelmann RK. Alopecia areata – An evaluation of 736 patients. Arch Dermatol. 1963;88:290-7. </li> <li style="text-align:justify">Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update: Part I. Clinical picture, histopathology,and pathogenesis. J Am Acad Dermatol. 2010;62:177-88.</li> <li style="text-align:justify">Tosti A, La Placa M, Placucci F, Gentilomi G, Venturoli S, Zerbini M. No correlation between CMV and alopecia areata. J Invest Dermatol. 1996;107:443.</li> <li style="text-align:justify">Trost LB, Bergfeld WF, Calogeras E. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. J Am Acad Dermatol. 2006;54:824-44. </li> <li style="text-align:justify">McElwee KJ, Sinclair R. Hair physiology and its disorders. Drug Discov Today Dis Mech 2008;5:e163-71.</li> <li style="text-align:justify">Mitchell A, Douglas M. Topical photochemotherapy for alopecia areata. J Am Acad Dermatol.1985; 12: 644-649.</li> <li style="text-align:justify">Papandopoulos AJ, Schwartz RA, Krysicka-Janniger C. Alopecia areata: emerging concepts. Acta Dermatoven Alp Panonnen Adriad. 2000; 9: 3-11.</li> <li style="text-align:justify">Swarnlata S, Manjusha J, Anshita G, Vishal J, Shailendra S.(2014). Herbal Hair Cosmetics: Advancements and recent findings. World Journal of Pharmaceutical Research,3(2), 3279-3286.</li> </ol>

International Journal of Advances in Microwave Technology

Abstract

REVIEW ON THERAPEUTIC ADVANCEMENTS OF ALOPECIA AREATA (AA)

SURESH YADAV K*, VENKATESWARA REDDY B, SHAJAHA SK, RAVI B, SUDHAKAR M, MOULASAB P, MAHESH BABU