FORMULATION AND DEVELOPMENT OF DENTAL GEL CONTAINING CLOVE OIL FOR THE TREATMENT OF HUMAN PERIODONTAL DISEASES

VIJAYA KUMAR VOLETI*; SANA BANU SHAIK; CHANDANA KONDURU; SATHISH PEYAM; CHARAN KUMAR YARAMSETTI; SUBRAMANYAM PASALA; SHANMUGA PANDIYAN PITCHAIMUTHU

Abstract

JOURNAL OF COMPREHENSIVE PHARMACY - Vol 3, Issue 1, 2016

Pages: 1-7

FORMULATION AND DEVELOPMENT OF DENTAL GEL CONTAINING CLOVE OIL FOR THE TREATMENT OF HUMAN PERIODONTAL DISEASES

VIJAYA KUMAR VOLETI*, SANA BANU SHAIK, CHANDANA KONDURU, SATHISH PEYAM, CHARAN KUMAR YARAMSETTI, SUBRAMANYAM PASALA, SHANMUGA PANDIYAN PITCHAIMUTHU

Category:

Download PDF

Abstract:

Aim: The study was aimed to develop and evaluate dental gel containing clove oil as the chief constituent for the treatment of periodontitis.

Methods: It has a wide spectrum of antibacterial activity against a number of periodontal pathogens, hence it is selected for the treatment of periodontitis. Clove oil gel is formulated by using carbopol 934 as gelling agent, clove oil as medicinal agent, polyethylene glycol co-solvent, methyl paraben and propyl paraben as preservative and required quantity of distilled water as vehicle.

Results: The clove oil was evaluated for physical parameters like acid value, ester value, specific gravity and refractive index and it shown satisfactory results. The prepared gel was evaluated for various properties such as antimicrobial activity, pH, spreadability, extrudability, drug content etc. In-Vitro experiments demonstrated that the formulation F3 is a suitable dosage form for the treatment of periodontitis. Clove oil showed the zone of inhibition of about 22.05±0.04 mm.

Conclusion: On the basis of the result obtained in this present study we conclude that the gel formulations of clove oil F3 showed good physicochemical properties as well as good drug content compared to other formulations.

Keywords: Clove oil, Carbopol 934, Periodontitis, Anti microbial activity.

References:<ol> <li style="text-align:justify">Chaieb K, Hajlaoui H, Zmantar, Khla-Nakbi AB, Rouabhia M, Mahdouani K et al. The Chemical Composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): A short review. Phytother Res. 2007;21(6):501-506.</li> <li style="text-align:justify">Gupta AK, Tandon Neeraj, Sharma Madhu. Quality Standards of Indian Medicinal plants, Indian Council of Medical Research, New Delhi. 2011:3.</li> <li style="text-align:justify">Pawar VA, Bhagat TB, Toshniwal MR, Mokashi ND, Khandelwal KR. Formulation and evaluation of dental gel containing essential oil of coriander against oral pathogens. Int Res J Pharm. 2013;4(10):48-54.</li> <li style="text-align:justify">Sharma A, Dwivedi S, Mishra GP, Joshi H. Formulation and Evaluation of Herbal Gel containing Extracts of Albezia Lebbeck linn. Am J Pharm Tech Res. 2012;2(4):663-668.</li> <li style="text-align:justify">Gupta N, Patel AR, Ravindra RP. Design of Akkalkara (Spilanthes acmella) formulations for antimicrobial and topical anti-inflammatory activities. Int J Pharm Bio Sci 2012;3(4):161-170.</li> <li style="text-align:justify">Patil SC, Gadade DD, Rathis PB. Design, Development and Evaluation of Herbal Gel for Treatment of Psoriasis. JIPBS. 2015; l2(1):72-87.</li> <li style="text-align:justify">Misal G, Dixit G, Gulkarni V. Formulation and Evaluation of herbal gel. Indian J nat prod resour. 2012;3(4):501-505.</li> <li style="text-align:justify">Das K, Dang R, Machale MU. Formulation and Evaluation of A Novel Herbal Gel Of Stevia Extract. Iranian Journal of Dermatology. 2009;12(4):117-122.</li> <li style="text-align:justify">Dheepika B, Uma Maheswari TN. Aloe Vera in Oral Diseases - A Review. Int J Pharm Pharm Sci. 2014;6(2):64-66.</li> <li style="text-align:justify">Mastiholimath VS, Dandagi PM, Gadad AP, Patil MB, Manvi FV, Chandur VK. Formulation and evaluation of ornidazole dental implants for periodontitis. Ind J Pharm Sci. 2006;68(1):68-71.</li> <li style="text-align:justify">Shefali K, Sumeet D. Indigeneous ayurvedic knowledge of some species in the treatment of human disease and disorders. Int J Pharm Life Sci. 2010;1(1):44-49.</li> <li style="text-align:justify">Ates DA, Erdogrul OT. Antimicrobial activities of various medicinal and commercial plant extracts. Turk J Biol. 2003;27:157-162.</li> <li style="text-align:justify">Ungphaiboon S, Supavita T, Singchangchai P, Sungkarak S, Rattanasuwan P, Itharat A. Study on antioxidant and antimicrobial activities of turmeric clear liquid soap for wound treatment of HIV patients. J Sci Technol. 2005;27(Suppl 2):569-578.</li> <li style="text-align:justify">Das K, Dang R, Machale UM, Fatepuri S. Formulation and evaluation of herbal gel containing Stevia leaves extract. The Pharma Review. 2010;8(44):112-118.</li> <li style="text-align:justify">Thanaboripat D, Suvathi Y, Srilohasin P, Sripakdee S, Patthanawanitchai O, Charoensettasilp S. Inhibitory effect of essential oils on the growth of Aspergillus flavus. KMITL Sci. Tech J. 2007;7(1):1-7.</li> <li style="text-align:justify">Satpathy B, Sahoo M, Sahoo P, Patra SR. Formulation and evaluation of gel containing essential oils of Piper betle against skin infection pathogens. Int J Res Phar Sci. 2011;2(3):373-378.</li> <li style="text-align:justify">Mitra J, Mohammad RR, Hedayte S. Mucoadhesive and drug release properties of benzocaine gel. Iranian J Pharm Sci. 2006;2:185-194.</li> <li style="text-align:justify">Chauhan T, Parashar B , Arora S. Design and Evaluation of Diclofenac Sodium Gel. Int J Phar Sci 2013;2(1):72-81.</li> <li style="text-align:justify">Neel JM, Neel DP, Patel J, Shastri DH, Shelat PK. Development and Evaluation of Antiarthritic Herbal Ointment. RJPBCS 2013;4(1):221-228.</li> <li style="text-align:justify">Llewelyn J. A double-blind crossover trial on the effect of cetylpyridinium chloride 0.05 per cent (Merocet) on plaque accumulation. Br Dent J 1980;148(4):103- 104.</li> <li style="text-align:justify">Ashley FP, Skinner A, Jackson P, Woods A, Wilson RF. The effect of a 0.1% cetylpyridinium chloride mouthrinse on plaque and gingivitis in adult subjects. Br Dent J 1984;157(6):191-196. </li> <li style="text-align:justify">Moran J, Addy M, Kohut B, Hovliaras CA, Newcombe RG. Efficacy of mouthrinses in inhibiting the development of supragingival plaque over a 4-day period of no oral hygiene. J Periodontol 1994;65(10):904-907.</li> <li style="text-align:justify">Lobene RR, Kashket S, Soparkar PM, Shloss J, Sabine ZM. The effect of cetylpridinium chloride on human plaque bacteria and gingivitis. PharmacolTherDent. 1979;4(1):33-47. </li> </ol>

DOI URL: http://doi.org/10.37483/JCP.2016.3101

International Journal of Advances in Microwave Technology

Abstract

FORMULATION AND DEVELOPMENT OF DENTAL GEL CONTAINING CLOVE OIL FOR THE TREATMENT OF HUMAN PERIODONTAL DISEASES

VIJAYA KUMAR VOLETI*, SANA BANU SHAIK, CHANDANA KONDURU, SATHISH PEYAM, CHARAN KUMAR YARAMSETTI, SUBRAMANYAM PASALA, SHANMUGA PANDIYAN PITCHAIMUTHU